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Reactive Intermediates - Carbocations, Carbanions, Free Radicals | CurlyArrows

Reactive Intermediates - Carbocations, Carbanions, Free Radicals | CurlyArrows

 

Why this chapter?

A chemical reaction always begins with a reactant (starting material), which triggers a chemical response when a suitable reagent is added. 

Sometimes, these chemical reactions do not happen in a single step and require multiple steps that go through intermediates. These intermediates are called the ‘Reactive Intermediates’ and are essential for converting reactants into products. 

The chapter on ‘Reactive Intermediates’ discusses some of the most important types - Carbocation, Carbanion, and Free Radical (carbon-based).

The reactive intermediate controls reaction rates and even influences the product outcome. The polythene bag for groceries or the PVC pipe transporting water was made using a reactive intermediate called free radicals. Reactive intermediate like carbocation is involved when any foreign substance enters our body, and it is safely removed by the liver enzymes to avoid any harm. Metronidazole, a drug used to treat various infections, uses a carbanion intermediate for its synthesis. 

This chapter explores the most common types, their stability, and the types of reactions they undergo.

  • Carbocation- Introduction, Nature, and Types
  • Formation of Carbocation
  • Stability of Carbocations- Inductive, Resonance, and Hyperconjugation
  • Other Structural Features Increasing Carbocation Stability
  • Structural Feature Decreasing Carbocation Stability
  • Fate of the Carbocation
  • General Carbocation Formation Reactions
  • Carbanion- Introduction, Nature, and Types
  • Formation of Carbanions
  • Carbanion Stabilization
  • Ease of Formation of Carbanion -Acidic proton
  • Fate of the Carbanion
  • Free Radical- Introduction and Types of Carbon-Centred Radicals
  • Structure of Carbon-Centred Free Radical
  • Formation of Radicals
  • Stability of the Carbon-Centred Radicals
  • Other Structural Feature Increasing Free Radical Stability
  • Comparing Free Radical Stability using Dissociation energies (D-H) 
  • Fate of Free Radicals
  • Common Reactions Involving Carbon-Free Radicals
Introduction to Reactive Intermediates in Organic Chemistry
Carbocation- Introduction, Nature and Types
Formation of Carbocation
Stability of Carbocations- Inductive, Resonance, and Hyperconjugation
Other Structural Features Increasing Carbocation Stability
Structural Feature Decreasing Carbocation Stability
Fate of the Carbocation
General Carbocation Formation Reactions
Carbanion- Introduction, Nature and Types
Formation of Carbanions
Carbanion Stabilization
Ease of Formation of Carbanion -Acidic proton
Fate of the Carbanion
Free Radical- Introduction and Types of Carbon-Centered Radicals
Structure of Carbon-Centered Free Radical
Formation of Radicals
Stability of the Carbon-Centered Radicals
Other Structural Feature Increasing Free Radical Stability
Comparing Free Radical Stability using Dissociation energies (D-H)
Fate of Free Radicals
Common Reactions Involving Carbon-Free Radicals